What's Next In Health

Researchers have identified a key signaling molecule in the brain that appears to trigger the brain to "learn" a craving for cocaine. Their finding could offer an important target for drugs to treat addiction by short-circuiting that adaptive process.

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Researchers have developed a mouse strain in which the abnormal activity of the dopamine machinery in a specific part of the brain causes cognitive and behavioral impairments mimicking those in human schizophrenics.

The achievement is important, because creating an animal model of any schizophrenic characteristics has not been done before. And schizophrenia's genetic and physiological complexities have seriously hindered efforts to understand the disorder.

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A new study has found that supplements of vitamin C can largely stop the serious depletion of vitamin E that occurs in smokers, demonstrating for the first time in humans a remarkable interaction between these two antioxidants as they work together.

The research also suggests a possible mechanism by which smoking can cause cancer.

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Johns Hopkins researchers have announced the development of a Web-based, automated computer program that they say greatly simplifies the time-consuming and error-prone process of manually designing artificial pieces of DNA.

The program, called GeneDesign, guides the design of blueprints for DNA segments to the exacting specifications required for studying gene function and genetically engineering cells. The blueprints are then used by companies or other investigators to synthesize the gene.

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The widely used erectile dysfunction drug Levitra is now the second drug in its class found to protect the heart against tissue damage following acute heart attack, according to a new study by Virginia Commonwealth University researchers.

?Our findings further support the concept that the novel class of phosphodiesterase-5 inhibitors, or PDE-5 inhibitors, including Levitra and Viagra, may have a new utility in cardiac protection, in addition to their well-known use for the management of erectile dysfunction in men,? said Rakesh C. Kukreja, Ph.D., professor of medicine, physiology, biochemistry and emergency medicine at VCU. Kukreja is lead author of the study.

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Having a surgeon with four arms is one of the advantages of the latest robotic technology now being studied at UT Southwestern Medical Center.

The $1.4 million robot named da Vinci can hold a camera in one hand while manipulating tiny laparoscopic surgical tools in its other hands. And it never tires like its human counterparts.

With a human surgeon at the controls, da Vinci filters out tremor, enhances precision, offers three-dimensional imaging and eliminates the inverted manipulation of instruments usually required in laparoscopic procedures.

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In the March 1 issue, Drs. Johanna Joyce (MSKCC), Douglas Hanahan (UCSF) and colleagues lend new insight into how broad-spectrum cysteine cathepsin inhibitors combat pancreatic cancer, and provide new data to help refine the design of more precisely targeted anti-cathepsin therapies.

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Use of the weight-loss medication rimonabant produced modest yet sustained weight loss after 2 years, and improved HDL cholesterol and triglyceride levels, according to a study in the February 15 issue of JAMA.

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Intakes of dietary or supplemental antioxidants were not associated with a decreased risk of prostate cancer among men in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, according to a study in the February 15 issue of the Journal of the National Cancer Institute . The study did find that vitamin E and beta-carotene supplementation may be associated with reduced prostate cancer risk in certain population subgroups.

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A contrast agent currently used in magnetic resonance imaging (MRI), called mangafodipir, may increase the cancer-killing ability of some chemotherapy drugs while protecting normal cells, according to a study in the February 15 issue of the Journal of the National Cancer Institute .

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Various forms of human muscular dystrophy result from mutations in genes encoding proteins of the nuclear envelope. A new paper in the February 15th issue of G&D reveals how.

Ten human hereditary laminopathies, including Emery-Dreifuss muscular dystrophy (EDMD), are associated with mutations in the LMNA gene that codes for the nuclear filament proteins, lamins A and C. Dr. Brain Kennedy and colleagues at the University of Washington have used a mouse model of EDMD to elucidate the mechanism by which altered expression of A-type lamins causes progressive muscular degeneration.

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An innovative method of categorizing myosin?one of three molecular ?motors? that produce movement within the cells of the body?has dramatically increased the amount of information available about these essential proteins. The studies lay the groundwork for development of treatments for conditions ranging from certain kinds of blindness and kidney disease to neurodegenerative disorders and parasitic diseases such as malaria.

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Misfolded and damaged proteins are common to all human neurodegenerative diseases. Clumps of these aggregated proteins destroy neurons within the brain and cause disease. But explanations for the mechanism that actually causes cell death have varied widely, puzzling scientists and leading them to ask whether Alzheimer's, Parkinson's, Huntington's and Creutzfeldt-Jakob diseases and familial amyotrophic lateral sclerosis (ALS) are related diseases or very different diseases.

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Fighting with your spouse in front of your kids, or even ignoring each other, leads to negative thoughts and distress in your kids about your marriage and family today and even one year later. That's one of the major findings from researchers at the University of Rochester in New York and the University of Notre Dame in their study on marital conflict and its effects on children published in the January/February 2006 issue of the journal Child Development.

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